Neuropathic Bladder, Bladder Reconstruction, Research in Regenerative Urology, and Pediatric Voiding Disorders.

We are proud to present an international faculty of well-known specialists coming from clinical practice and research.

Dysfunctional voiding is a frequent condition in childhood and systematically underdiagnosed. Despite growing literature there is still confusion regarding diagnosis and treatment. We hope we can contribute to the discussion and find some practical consensus.

Treatment of neuropathic bladder is complex, challenging and sometimes frustrating. We try to focus on all the relevant topics of neuropathic bladder like anatomy, neurology, pathophysiology, urodynamic evaluation and treatment options.

We try to focus on several aspects of bladder surgery and urogenital reconstruction: augmentation, epispadias repair, extrophy and surgery for continence. Experts will critically share their experience.

Last but not least, we are very proud to invite you to the workshop –

Establishing Research in Pediatric Urology.

 These days scientific output becomes more and more important. However, for young researchers it is not easy to start projects without guidance or within already existing structures. In this workshop we try to cover all aspects of clinical and experimental research with special emphasis on the questions of young investigators: What is a good topic? How to write a paper? What journal? Collaboration, ethics and funding etc. We are sure that there will be time for networking and perhaps you will leave PESPOS with new ideas and spirit.

Vienna in December is amazing. Walk through the historic city. Enjoy the opera or one of the world famous museums. Do some Christmas shopping and visit one of the atmospheric Christmas markets. We will arrange a memorable social program.

 

We look back on to a wonderful time! 

 

Topics were covered:

  • Pathophysiology of neuropathic bladder

  • Fetal MRI

  • Urodynamic investigations

  • Non-surgical treatment of neuropathic bladder

  • Surgical treatment of neuropathic bladder

  • Techniques of bladder reconstruction

  • Strategies to avoid bladder reconstruction

  • How to run an interdisciplinary service for children with neuropathic bladder

  • The future of bladder reconstruction (tissue engineering and others)

  • Management of chronic renal failure in children with neuropathic bladder

  • Quality of life issues in neuropathic bladder

  • Obstructive uropathy and reflux nephropathy - molecular basis and clinical implication

 

  • Practical course:
  • How to establish a research project in pediatric surgery - from the idea to the grant and from frustration to fun.
 


Peter Brugger, Vienna/Austria
Shahrokh Shariat,
Vienna/Austria

Marleen van den Heijkant
, The Hague/The Netherlands
Dagmar Csaicsich, Vienna/Austria
Peter Vajda
, Pecs/Hungary
Wolfgang Rösch,Regensburg/Germany

Mark Koen, Linz/Austria
Shumyle Alam - Cinncinati/United States
Ramnath Subramaniam, Leeds/UK

T.P.V.M.  de Jong
, Utrecht/The Netherlands
Angelika Etele-Hainz, Vienna/Austria
Alexander Springer
, Vienna/Austria
Ricardo Gonzalez, Berlin/Germany
Grzegorz Kudela
,
Katowice/Poland

Priv. Doz. Mag. DDr. Peter Brugger, Vienna/Austria
Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria

Specialist in Fetal MRI Imaging
Medline
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Alexander Springer - Medical University of Vienna/Austria
FEAPU
Consultant Pediatric Urologist
Assistant Professor of Pediatric Surgery, Medical University Vienna
2011-2012 Fellowship in Pediatric Urology in Leeds/UK
Special interest: urogenital reconstruction
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Ricardo Gonzalez, Berlin/Germany
Urology training at the University of Minnesota, USA
Professor of Urology and Pediatrics, University of Minnesota, USA
Chief of Pediatric urology at the Children’s Hospital of Michigan
Professor of Urology at Thomas Jefferson University
Consultant in pediatric urology at the Children’s Hospital of the University of Zurich
Consultant in pediatric urology at  University of Berlin
Visiting professor at 30 Universities
author of more 400 publications including more than 220 peer reviewed papers and 69 book chapters and has edited 3 books.

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Grzegorz Kudela
-
Department of Paediatric Surgery, Katowice/Poland
FEAPU
Consultant Pediatric Surgeon and Urologist, Katowice Children's Hospital, Silesian Medical University Katowice/Poland
Special interest: Urogenital reconstruction, spina bifida
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Dagmar Csaicsich
- Department of Pediatric Nephrology, Vienna/Austria
Consultant of Pediatric Nephrologist, Medical University Vienna
Medline
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T.P.V.M.  de Jong
, University Children's Hospital UMC, Utrecht/The Netherlands

FEAPU
Professor of Paediatric Urology, Amsterdam University
Articles
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Ramnath Subramaniam,
St. James University Hospital and Leeds Teaching Hospitals, Leeds/UK
Consultant Pediatric Urologist, FRCSI, FRCS (Paed), FEAPU
Chairman Educational Committee of the ESPU
Special interest: Reconstructive Paediatric Urology, Urothelial tissue engineering, Minimally invasive surgery
Articles

Seromuscular grafts for bladder reconstruction: extra-luminal demucosalisation of the bowel.

Subramaniam R
, Turner AM, Abbas SK, Thomas DF, Southgate J.
Urology. 2012 Nov;80(5):1147-50
Tissue engineering potential of urothelial cells from diseased bladders.

Subramaniam R
, Hinley J, Stahlschmidt J, Southgate J.
J Urol. 2011 Nov;186(5):2014-20
Efficacy of bladder irrigation and surveillance program in prevention of urinary tract infections and bladder calculi in children with an ileocystoplasty and bladder neck repair.

van den Heijkant M, Haider N, Taylor C, Subramaniam R.
Pediatr Surg Int. 2011 Jul;27(7):781-5
Endoscopic insertion of cystostomy button for bladder drainage in children.

Haider N, Subramaniam R.
J Pediatr Urol. 2008 Dec;4(6):457-9
Cystostomy button for bladder drainage in children.

Milliken I, Munro NP, Subramaniam R.
J Urol. 2007 Dec;178(6):2604-6
Functional and cosmetic outcome of the VQ plasty for Mitrofanoff stomas.

England RJ, Subramaniam R.
J Urol. 2007 Dec;178(6):2607-10
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Shumyle Alam - Cinncinati Childrens Hospital, United States
Clinical Director, Urogenital Center
Assistant Professor
, UC Department of Pediatrics
Special interest: Complex genitourinary reconstruction; spina bifida; neurogenic bladder; anorectal malformations, disorders of sexual development; cloaca; renal transplantation in the neurogenic bladder
Website
Articles

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Mark Koen, Department of Pediatric Urology, Linz/Austria
FEAPU
Consultant Pediatric Urologist, Department of Pediatric Urology, Linz/Austria
Special interest in neuropathic bladder, voiding disorders and urodynamic studies
Articles
The role of the Lich-Gregoir procedure in refluxing duplicated collecting systems: experience from long-term follow up of 45 children.

Berger C, Koen M, Becker T, Mitter K, Riccabona M.
J Pediatr Urol. 2008 Aug;4(4):265-9
[Minimally invasive, safe treatment of the neurogenic bladder with botulinum-A-toxin in children with myelomeningocele]
Lusuardi L, Nader A, Koen M, Schrey A, Schindler M, Riccabona M.
Aktuelle Urol. 2004 Feb;35(1):49-53.
Botulinum-A toxin injection into the detrusor: a safe alternative in the treatment of children with myelomeningocele with detrusor hyperreflexia.
Riccabona M, Koen M, Schindler M, Goedele B, Pycha A, Lusuardi L, Bauer SB.
J Urol. 2004 Feb;171(2 Pt 1):845-8; discussion 848.
[Bladder exstrophy-epispadias complex: management and preliminary results]
Riccabona M, Lusuardi L, Beckers G, Koen M.
Aktuelle Urol. 2003 Oct;34(6):402-6
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Wolfgang Rösch
,Regensburg/Germany
FEAPU
Head of Department of Pediatric Urology in Regensburg/Germany
Professor in Pediatric Urology
Articles
Candidate gene association study implicates p63 in the etiology of nonsyndromic bladder-exstrophy-epispadias complex.

Qi L, Wang M, Yagnik G, Mattheisen M, Gearhart JP, Lakshmanan Y, Ebert AK, Rösch W, Ludwig M, Draaken M, Reutter H, Boyadjiev SA.
Birth Defects Res A Clin Mol Teratol.
Isolated bladder exstrophy associated with a de novo 0.9 Mb microduplication on chromosome 19p13.12.
Draaken M, Mughal SS, Pennimpede T, Wolter S, Wittler L, Ebert AK, Rösch W, Stein R, Bartels E, Schmidt D, Boemers TM, Schmiedeke E, Hoffmann P, Moebus S, Herrmann BG, Nöthen MM, Reutter H, Ludwig M.
[Transition of adolescents with the exstrophy-epispadias complex to adult medicine: influence of long-term outcome results on management].

Ebert AK, Reutter H, Neissner C, Rösch W.
Klin Padiatr. 2012 Nov;224(7):455-60.
Assisted reproductive techniques and risk of exstrophy-epispadias complex: a German case-control study.

Zwink N, Jenetzky E, Hirsch K, Reifferscheid P, Schmiedeke E, Schmidt D, Reckin S, Obermayr F, Boemers TM, Stein R, Reutter H, Rösch WH, Brenner H, Ebert AK.
J Urol. 2013 Apr;189(4):1524-9.
Testicular tumors in patients with exstrophy-epispadias complex.
Ebert AK, Kliesch S, Neissner C, Reutter H, Rösch WH.
J Urol. 2012 Oct;188(4):1300-5.
Satisfaction with genital surgery and sexual life of adults with XY disorders of sex development: results from the German clinical evaluation study.
Köhler B, Kleinemeier E, Lux A, Hiort O, Grüters A, Thyen U; DSD Network Working Group.
J Clin Endocrinol Metab. 2012 Feb;97(2):577-88
Pregnancy management in women within the bladder-exstrophy-epispadias complex (BEEC) after continent urinary diversion.
Ebert AK, Falkert A, Hofstädter A, Reutter H, Rösch WH.
Arch Gynecol Obstet. 2011 Oct;284(4):1043-6
Phenotype severity in the bladder exstrophy-epispadias complex: analysis of genetic and nongenetic contributing factors in 441 families from North America and Europe.
Reutter H, Boyadjiev SA, Gambhir L, Ebert AK, Rösch WH, Stein R, Schröder A, Boemers TM, Bartels E, Vogt H, Utsch B, Müller M, Detlefsen B, Zwink N, Rogenhofer S, Gobet R, Beckers GM, Bökenkamp A, Kajbafzadeh AM, Jaureguizar E, Draaken M, Lakshmanan Y, Gearhart JP, Ludwig M, Nöthen MM, Jenetzky E.
J Pediatr. 2011 Nov;159(5):825-831.e1.
Microduplications at 22q11.21 are associated with non-syndromic classic bladder exstrophy
Draaken M, Reutter H, Schramm C, Bartels E, Boemers TM, Ebert AK, Rösch W, Schröder A, Stein R,
Moebus S, Stienen D, Hoffmann P, Nöthen MM, Ludwig M.
Eur J Med Genet. 2010 Mar-Apr;53(2):55-60.
The exstrophy-epispadias complex.
Ebert AK, Reutter H, Ludwig M, Rösch WH. Orphanet J Rare Dis. 2009 Oct 30;4:23. doi: 10.1186/1750-1172-4-23. Review.
Long-term follow-up of male patients after reconstruction of the bladder-exstrophy-epispadias complex: psychosocial status, continence, renal and genital function.
Ebert AK, Schott G, Bals-Pratsch M, Seifert B, Rösch WH. J Pediatr Urol. 2010 Feb;6(1):6-10.
Pelvic-floor imaging using three-dimensional ultrasonography and magnetic resonance imaging in the  long term follow-up of the bladder-exstrophy-epispadias complex.
Ebert AK, Falkert A, Brandl R, Hirschfelder H, Koller M, Rösch WH.
BJU Int. 2010 Jan;105(2):248-53.
Biometry of the pubovisceral muscle and levator hiatus assessed by three-dimensional ultrasound in females with bladder exstrophy-epispadias complex after functional reconstruction.
Ebert AK, Falkert A, Germer U, Rösch WH.
Ultrasound Obstet Gynecol. 2009 Jul;34(1):98-103.
Possible association of Down syndrome and exstrophy-epispadias complex: report of two new cases and review of the literature.
Reutter H, Bökenkamp A, Ebert AK, Rösch W, Boemers TM, Nöthen MM, Ludwig M.
Eur J Pediatr. 2009 Jul;168(7):881-3. doi: 10.1007/s00431-008-0852-5. Epub 2008 Oct 16. Review.
Genital and reproductive function in males after functional reconstruction of the exstrophy-epispadias complex--long-term results
Ebert AK, Bals-Pratsch M, Seifert B, Reutter H, Rösch WH.
Urology. 2008 Sep;72(3):566-9; discussion 569-70. doi: 10.1016/j.urology.2007.11.166. Epub 2008 Jun 30
Epidemiological survey of 214 families with bladder exstrophy-epispadias complex
Gambhir L, Höller T, Müller M, Schott G, Vogt H, Detlefsen B, Ebert AK, Fisch M, Beaudoin S, Stein R,
Boyadjiev SA, Gearhart JP, Rösch W, Utsch B, Boemers TM, Reutter H, Ludwig M.
J Urol. 2008 Apr;179(4):1539-43
[Development of treatment for extrophy-epispadias in Germany]
Rösch WH, Ebert AK.
Urologe A. 2007 Dec;46(12):1691-6. German.
Concordance analyses of twins with bladder exstrophy-epispadias complex suggest genetic etiology
Reutter H, Qi L, Gearhart JP, Boemers T, Ebert AK, Rösch W, Ludwig M, Boyadjiev SA.
Am J Med Genet A. 2007 Nov 15;143A(22):2751-6. No abstract available.
Characteristic changes in the pattern of distribution of muscarinic receptors in the exstrophic bladder wall].
Rösch WH, Hagemann M, Hanisch I, Neuhuber WL.
Urologe A. 2007 Sep;46(9):1044-7. German. No abstract available.
Family-based association study of the MTHFR polymorphism C677T in the bladder-exstrophy-epispadias-complex.
Reutter H, Becker T, Ludwig M, Schäfer N, Detlefsen B, Beaudoin S, Fisch M, Ebert AK, Rösch W,
Nöthen MM, Boemers TM, Betz RC.
Am J Med Genet A. 2006 Nov 15;140(22):2506-9. No abstract available.
[Myelomeningocele--"the next years..."].
Körner I, Reuss A, Kuhn U, Wiedemayer H, Stolke D, Pförtner J, Löer FA, Rösch W, Rübben H.
Urologe A. 2006 Sep;45 Suppl 4:209-13. German. No abstract available.
[Bladder exstrophy--epispadias complex. New goals--new ways?].
Rösch WH, Ebert A, Schott G.
Urologe A. 2006 Sep;45 Suppl 4:219-24. German. No abstract available.
Bladder exstrophy-epispadias complex: Investigation of suppressor of variegation, enhancer of zesteand Trithorax (SET) as a candidate gene in a large cohort of patients.
Reutter H, Thauvin-Robinet C, Boemers TM, Rösch WH, Ludwig M.
Scand J Urol Nephrol. 2006;40(3):221-4.
[Rare variations in exstrophy-epispadias complex].
Rösch WH, Wiessmüller J, Leidl T, Schott G.
Urologe A. 2003 Mar;42(3):387-9. German. No abstract available.
A rare complex bladder exstrophy variant.
Rösch WH, Neuhuber WL.
BJU Int. 2001 Jan;87(1):127. No abstract available.
Management of failed bladder exstrophy closure in adolescence and adulthood.
Ebert A, Schott G, Hirschfelder H, Rösch WH.
BJU Int. 2000 Nov;86(7):901-4. No abstract available
Catheter-associated infections in urology: possible use of silver-impregnated catheters and the Erlanger silver catheter.
Rösch W, Lugauer S
Infection. 1999;27 Suppl 1:S74-7. Review.
[Tramadol infusion for pain therapy following bladder exstrophy surgery in pediatric wards].
Griessinger N, Rösch W, Schott G, Sittl R.
Urologe A. 1997 Nov;36(6):552-6. German.
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Shahrokh Shariat,
Vienna/Austria
Professor Urology Medical University Vienna
Chairman of the Department of Urology, Medical University Vienna
1998-2002 Scott Department of Urology, Baylor College of Medicine, Houston, TX
2002-2008 Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX
2008-2010 Division of Urology, Memorial Sloan-Kettering cancer Center, New York, NY
2010-2013 Department of Urology; The New York Presbyterian Hospital,Weill Medical College of Cornell University, NYC
Specialist in Urologic Onclogy, more than 550 scientfic publications
Pubmed
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Marleen van den Heijkant
, The Hague/The Netherlands
FEAPU
Consultant Pediatric Urologist, Juliana Children's Hospital The Hague/The Netherlands
Special Interest in Neuropathic Bladder, bladder reconstruction and genital surgery
Articles:
Vesicoscopic bladder neck procedure in children: what we have learned from the first series.

Chrzan R, Dik P, Klijn AJ, Kuijper CF, van den Heijkant MM, de Jong TP.
J Laparoendosc Adv Surg Tech A. 2013 Sep;23(9):803-7.
Introducing the HOPE (Hypospadias Objective Penile Evaluation)-score: A validation study of an objective scoring system for evaluating cosmetic appearance in hypospadias patients.

van der Toorn F, de Jong TP, de Gier RP, Callewaert PR, van der Horst EH, Steffens MG, Hoebeke P, Nijman RJ, Bush NC, Wolffenbuttel KP, van den Heijkant MM, van Capelle JW, Wildhagen M, Timman R, van Busschbach JJ. J Pediatr Urol. 2013 Mar 11.
Wrap plication of megaureter around normal-sized ureter for complete duplex system reimplantations.
van den Heijkant MM, Dik P, Klijn AJ, Chrzan R, Kuijper CF, de Jong TP.
J Urol. 2013 Jan;189(1):295-9.
Efficacy of bladder irrigation and surveillance program in prevention of urinary tract infections and bladder calculi in children with an ileocystoplasty and bladder neck repair.
van den Heijkant M, Haider N, Taylor C, Subramaniam R.
Pediatr Surg Int. 2011 Jul;27(7):781-5.
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Peter Vajda, Pecs/Hungary
FEAPU
Assistant Professor in Pediatric Surgery
Consultant Pediatric Surgeon, University Hospital Pecs/Hungary
Special Interest in neuropathic bladder
Extensive experience in animal model of bladder replacement
Articles:
Composite urinary reservoir in dogs: histological findings.

Kispal ZF, Vajda P, Kereskai L, Jakab CS, Vastyan AM, Juhasz Z, Pinter AB.
J Urol. 2012 Mar;187(3):1110-5.
Complications after bladder augmentation or substitution in children: a prospective study of 86 patients.
Kispal Z, Balogh D, Erdei O, Kehl D, Juhasz Z, Vastyan AM, Farkas A, Pinter AB, Vajda P.
BJU Int. 2011 Jul;108(2):282-9.
Quality of life: urinary bladder augmentation or substitution in children.
Vajda P
, Kispal Z, Lenart I, Farkas A, Vastyan AM, Pinter AB.
Pediatr Surg Int. 2009 Feb;25(2):195-201.
Does the type of bladder augmentation influence the resolution of pre-existing vesicoureteral reflux? Urodynamic studies.
Juhasz Z, Somogyi R, Vajda P, Oberritter Z, Fathi K, Pinter AB.
A therapeutic method for failed bladder augmentation in children: re-augmentation.
Vajda P
, Buyukunal CS, Soylet Y, Danismed N, Juhasz Z, Pinter AB.
BJU Int. 2006 Apr;97(4):816-9, discussion 819.
Histologic findings after gastrocystoplasty in rabbits.
Vajda P
, Pinter AB, Magyarlaki T, Vastyan AM, Juhasz Z, Oberritter Z, Fathi K.
J Pediatr Surg. 2005 Sep;40(9):1470-4.
Cutaneous vesicostomy revisited--the second 15 years.
Vastyan AM, Pinter AB, Farkas A, Vajda P, Somogyi R, Juhasz Z.
Eur J Pediatr Surg. 2005 Jun;15(3):170-4.
Can epithelized neobladder-cutaneous fistula provide urinary continence?
Pintér A, Vajda P, Kroowand L, Farkas A.
Int J Urol. 2005 Jan;12(1):101-3.
Metabolic findings after colocystoplasty in children.
Vajda P
, Pinter AB, Harangi F, Farkas A, Vastyan AM, Oberritter Z.
Urology. 2003 Sep;62(3):542-6; discussion 546.
Seromuscular gastrocystoplasty in dogs.
Vastyan AM, Pinter AB, Farkas AP, Vajda P, Lantos J, Mehes G, Roth E.
Urol Int. 2003;71(2):215-8.
Histological findings after colocystoplasty and gastrocystoplasty.

Vajda P
, Kaiser L, Magyarlaki T, Farkas A, Vastyan AM, Pinter AB.
J Urol. 2002 Aug;168(2):698-701; discussion 701.
[Intermediate results of surgical bladder augmentation in children].
Farkas A, Pintér A, Vajda P, Juhász Z, Vástyán A, Oberritter Z.
Orv Hetil. 2001 Jul 29;142(30):1617-21. Hungarian.
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